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Specific Drugs That React With Augmentin ES

Allopurinol (Aloprim, Zyloprim)
Combining allopurinol with antibiotics similar to Augmentin ES increases the risk of skin rashes. It is not known if this is also true with Augmentin ES.
 
Methotrexate (Rheumatrex, Trexall)
Penicillin-type antibiotics (including Augmentin ES) may decrease the body's ability to remove methotrexate, leading to high blood levels of methotrexate. Your healthcare provider may need to monitor you more closely.
 
Mycophenolate Mofetil
Augmentin ES may decrease the effectiveness of mycophenolate mofetil. Check with your healthcare provider before taking these two medications together.
 
Oral Contraceptives
Despite the longstanding belief that antibiotics interact with birth control pills, several studies have shown that most antibiotics do not increase the risk of pregnancy in women taking birth control pills. Nevertheless, there have been reports of birth control pill failure in women who have taken antibiotics. Ask your healthcare provider about whether you should use a backup method of birth control.
 
Oral Typhoid Vaccine
Augmentin ES may decrease the effectiveness of the oral typhoid vaccine. If you are taking Augmentin ES, your oral typhoid vaccine may need to be postponed for at least a day after stopping the antibiotic.
 
Probenecid (Benuryl)
Probenecid can decrease the body's ability to remove Augmentin ES from the blood, potentially leading to high levels of Augmentin ES in the blood. Talk with your healthcare provider before taking these medications together.
 
Tetracycline Antibiotics
Tetracyclines may interfere with the effectiveness of Augmentin ES. Discuss this possibility with your healthcare provider before taking Augmentin ES with a tetracycline.
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Augmentin ES Medication Information

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