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Cipro HC Warnings and Precautions

People who have a perforated eardrum should not use Cipro HC. Precautions and warnings also apply to women who are pregnant or breastfeeding, as well as people with certain allergies. If your symptoms do not improve within a week of taking Cipro HC, contact your healthcare provider. You may need a different medication.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to using Cipro® HC (ciprofloxacin/hydrocortisone) if you have:
  • A hole in your eardrum or have ear tubes
  • Any allergies, including to medications, foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
In addition, tell your healthcare provider about any other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With Cipro HC

Some warnings and precautions to be aware of prior to using this medication include the following:
  • Cipro HC is an ear drop and should only be used in the ears. Do not take it by mouth, put it in your nose or eyes, or apply it to your skin.
  • Cipro HC does not kill all the types of organisms that may cause an ear infection. Therefore, if your infection seems to get worse, or if it has not improved within a week, talk to your healthcare provider. You may need a different medication.
  • In rare cases, this drug may cause a fungal or yeast infection. Contact your healthcare provider if you experience persistent discomfort or itching in your ears, or notice pus coming from your ears. Also, contact your healthcare provider if you notice white patches in your mouth or throat or flaky, itchy, or red skin.
  • When taken orally, medications like ciprofloxacin (one of the active ingredients in Cipro HC) have been reported to cause severe allergic reactions. Seek immediate medical attention if you develop any signs of an allergic reaction, such as:
    • Rash or hives
    • Itching
    • Swelling of the lips or throat
    • Wheezing
    • Difficulty breathing.
  • Cipro HC is unlikely to react with other medications (see Cipro HC Drug Interactions).
  • Cipro HC is a pregnancy Category C medication, which means that it may not be safe for use during pregnancy, although the full risks are currently unknown (see Cipro HC and Pregnancy for more information).
  • It is unknown if this medication passes through breast milk. Therefore, if you are breastfeeding or plan to start, talk to your healthcare provider before beginning treatment (see Cipro HC and Breastfeeding).
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