Ear Home > Augmentin ES

Augmentin ES is a type of antibiotic used to treat persistent or recurrent ear infections in children. This prescription medication contains two active ingredients, and works to kill bacteria by stopping the bacteria from making cell walls. This drug comes in liquid form and is typically taken twice daily. Potential side effects include vomiting, diarrhea, and yeast infections.

What Is Augmentin ES?

Augmentin ES® (amoxicillin/clavulanate potassium ES) is a prescription antibiotic approved to treat persistent or recurrent ear infections in children. The "ES" stands for "extra strength."
 
(Click Augmentin ES Uses for more details, including information about possible off-label uses.)
 

Who Makes This Medication?

Brand-name Augmentin ES is made by GlaxoSmithKline. Generic versions (made by various manufacturers) are also available.
 

How Does Augmentin ES Work?

Augmentin ES contains two different medications, amoxicillin and clavulanate potassium (also known as clavulanic acid, or simply clavulanate). Amoxicillin belongs to a group of medications known as aminopenicillins, which is part of a larger group of medications known as beta-lactam antibiotics (named after the ring-like "lactam" structure of these antibiotics).
 
Amoxicillin works by stopping bacteria from making cell walls, which eventually causes the bacteria to die. However, many bacteria have developed a resistance to amoxicillin (and similar antibiotics) by producing enzymes called beta-lactamases. Beta-lactamases (produced by bacteria) break the beta-lactam ring, making amoxicillin (and similar antibiotics) ineffective.
 
The other component of Augmentin ES (clavulanate) is known as a beta-lactamase inhibitor. Clavulanate stops the bacterial enzymes from breaking down the amoxicillin molecule. Clavulanate itself has no significant antibacterial activity; it merely helps to prevent amoxicillin from being broken down by bacteria that would otherwise be resistant to amoxicillin. Essentially, clavulanate "augments" the activity of amoxicillin (hence the name Augmentin).
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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